Lupus-like presentation of parvovirus B19 infection

Semin Arthritis Rheum. 2005 Feb;34(4):642-8. doi: 10.1016/j.semarthrit.2004.07.008.


Objectives: To describe 2 cases of parvovirus B19 (B19) infection mimicking systemic lupus erythematosus (SLE) and to identify all cases of SLE imitated by and/or associated with B19 in the medical literature.

Methods: A computer-assisted (PubMed) search of the medical literature from 1975 to 2003 was performed using the following key words: parvovirus, B19, SLE, lupus, antibodies, auto-immunity.

Results: Thirty-eight patients were identified: 35 women, 3 men; mean age = 28.8 years. Clinical manifestations were as follows: fever (24 patients); articular involvement (36 patients); cutaneous lesions (28 patients); lymphadenopathy (9 patients); hepato- and/or splenomegaly (6 patients); serositis (6 patients); renal involvement (4 patients); cerebral impairment (10 patients). Cytopenia was observed in 23 cases. Antinuclear antibodies were detected in 34 patients, anti-double-stranded DNA antibodies in 20 patients, anti-Sm antibodies in 4 patients, antinuclear ribonucleoprotein antibodies in 5 patients, anti-Ro-SSA antibodies in 4 patients, anti-La-SSB antibodies in 4 patients, and anticardiolipin and/or anti-beta2-glycoprotein I antibodies in 8 patients. Hypocomplementemia was found in 15 of 26 patients. In 19 cases, the B19 infection had a self-limiting course. In 6 cases, B19 infection occurred in a context of previously established SLE, simulating SLE exacerbation. In 6 observations, symptoms persisted several months after the viral infection. In 7 cases, the exact relationship between SLE and B19 could not be determined.

Conclusions: B19 infection may present a clinical and serological tableau making it difficult to distinguish between a viral infection and the first episode of SLE. Although B19 may modulate the clinical and biological features of rheumatic disease, studies in large series do not support a causative role for B19 in the pathogenesis of SLE.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Antibodies, Antinuclear / blood
  • Antibodies, Viral / blood
  • DNA, Viral / blood
  • Diagnosis, Differential
  • Female
  • Humans
  • Immunoglobulin M / blood
  • Lupus Erythematosus, Systemic / diagnosis*
  • Male
  • Parvoviridae Infections / diagnosis*
  • Parvoviridae Infections / virology
  • Parvovirus B19, Human* / genetics
  • Parvovirus B19, Human* / immunology


  • Antibodies, Antinuclear
  • Antibodies, Viral
  • DNA, Viral
  • Immunoglobulin M