Temporal and spatial patterning of an organ by a single transcription factor

Genome Biol. 2005;6(2):205. doi: 10.1186/gb-2005-6-2-205. Epub 2005 Jan 25.


During the formation of animal organs, a single regulatory factor can control the majority of cell-fate decisions, but the mechanisms by which this occurs are poorly understood. One such regulator, the nematode transcription factor PHA-4, functions together with various cis-regulatory elements in target genes to regulate spatial and temporal patterning during development of the pharynx.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Body Patterning / genetics
  • Caenorhabditis elegans / embryology*
  • Caenorhabditis elegans / genetics*
  • Caenorhabditis elegans Proteins / physiology*
  • Gene Expression Regulation, Developmental*
  • Models, Genetic
  • Organogenesis / genetics
  • Pharynx / embryology
  • Pharynx / metabolism
  • Regulatory Elements, Transcriptional
  • Trans-Activators / physiology*
  • Transcription, Genetic


  • Caenorhabditis elegans Proteins
  • Pha-4 protein, C elegans
  • Trans-Activators