Interaction of Helicobacter Pylori With Host Cells: Function of Secreted and Translocated Molecules

Curr Opin Microbiol. 2005 Feb;8(1):67-73. doi: 10.1016/j.mib.2004.12.004.

Abstract

Secreted proteins are of general interest from the perspective of bacteria-host interaction. The gastric bacterial pathogen Helicobacter pylori uses a set of secreted and translocated proteins--including outer membrane adhesins, secreted extracellular enzymes and translocated effector proteins--to adapt to its extraordinary habitat, the gastric mucosa. Two major virulence factors of H. pylori are the vacuolating cytotoxin (VacA) and the cag type-IV secretion system and its translocated effector protein, cytotoxin-associated antigen A (CagA). VacA targets not only epithelial cells, but also cells of the immune system and induces immunosuppression. CagA has been shown to interact with a growing set of eucaryotic signaling molecules in phosphorylation-dependent and -independent ways.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bacterial Proteins / metabolism*
  • Gastric Mucosa / immunology
  • Gastric Mucosa / microbiology*
  • Helicobacter Infections / microbiology
  • Helicobacter pylori / metabolism
  • Helicobacter pylori / pathogenicity*
  • Helicobacter pylori / physiology
  • Humans
  • Signal Transduction
  • Virulence Factors / metabolism*

Substances

  • Bacterial Proteins
  • Virulence Factors