Mice lacking D-amino acid oxidase activity display marked attenuation of stereotypy and ataxia induced by MK-801

Atsushi Hashimoto; Masanobu Yoshikawa; Akira Niwa; Ryuichi Konno

doi:10.1016/j.brainres.2004.11.031

Mice lacking D-amino acid oxidase activity display marked attenuation of stereotypy and ataxia induced by MK-801

Brain Res. 2005 Feb 8;1033(2):210-5. doi: 10.1016/j.brainres.2004.11.031.

Authors

Atsushi Hashimoto¹, Masanobu Yoshikawa, Akira Niwa, Ryuichi Konno

Affiliation

¹ Department of Pharmacology, School of Medicine, Tokai University, Isehara, Kanagawa 259-1143, Japan. hashimoto@is.icc.u-tokai.ac.jp

PMID: 15694926
DOI: 10.1016/j.brainres.2004.11.031

Abstract

The behavioral effects produced by MK-801 (0.4 mg/kg) were compared in mutant DAO-/- mice lacking D-amino acid oxidase activity and normal DAO+/+ mice. Mutant mice display marked diminution of stereotypy and ataxia induced by MK-801 compared to normal mice. Because the D-serine level in the brain of mutant mice is significantly higher than that of normal mice, the elevated D-serine in the brain of mutant mice could antagonize MK-801-induced stereotypy and ataxia.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Ataxia / chemically induced
Ataxia / enzymology*
Ataxia / genetics
D-Amino-Acid Oxidase / deficiency*
D-Amino-Acid Oxidase / genetics
Dizocilpine Maleate / toxicity*
Locomotion / drug effects
Locomotion / physiology
Male
Mice
Mice, Mutant Strains
Stereotyped Behavior / drug effects
Stereotyped Behavior / physiology*

Substances

Dizocilpine Maleate
Dao1 protein, mouse
D-Amino-Acid Oxidase