Time-frequency analysis of the surface electrocardiogram for monitoring antiarrhythmic drug effects in atrial fibrillation

Am J Cardiol. 2005 Feb 15;95(4):526-8. doi: 10.1016/j.amjcard.2004.10.025.


This study explored time-frequency analysis of surface electrocardiograms in patients with persistent atrial fibrillation for monitoring atrial drug action. Drug loading over 3 days with oral flecainide (n = 13) or amiodarone (n = 17) organized the fibrillatory process expressed by decreased atrial fibrillatory rate, increased rate stability, and decreased exponential decay. Effects were more pronounced with flecainide than with amiodarone.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Amiodarone / therapeutic use
  • Anti-Arrhythmia Agents / therapeutic use*
  • Atrial Fibrillation / drug therapy*
  • Atrial Fibrillation / physiopathology
  • Drug Monitoring / methods*
  • Electrocardiography*
  • Female
  • Flecainide / therapeutic use
  • Humans
  • Male
  • Middle Aged


  • Anti-Arrhythmia Agents
  • Flecainide
  • Amiodarone