Prevalence of IgM antibodies to phenolic glycolipid I among household contacts and controls in Korea and the Philippines

Lepr Rev. 1992 Mar;63(1):12-20. doi: 10.5935/0305-7518.19920003.


Phenolic glycolipid I (PGL-I) is a Mycobacterium leprae-specific antigen and the antibodies to the antigen may suggest an M. leprae infection. To compare the M. leprae transmission among the populations, we compared the prevalence of anti-PGL-I IgM antibodies among household contacts and controls between Korea and the Philippines. In Korea (prevalence of leprosy--0.04: 1000), the prevalence of anti-PGL-I antibodies were 4.8% among controls and 8.0% among contacts, respectively. On the other hand, the seroprevalence rate was 10.8% among controls and 13.4% among contacts in the Philippines (prevalence of leprosy--0.70: 1000). Interestingly, a marked difference was noted in the prevalance of anti-PGL-I antibodies among children between the countries; 10-14% among children under 10 years old and 15-18% among those aged between 10 and 19 in the Philippines compared to 0% and 2.9-6.4% in Korea, respectively. This study, therefore suggests that a high prevalance of anti-PGL-I IgM antibodies among children may indicate an active transmission of M. leprae, resulting in a higher incidence of leprosy in the population.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Antigens, Bacterial / immunology
  • Child
  • Child, Preschool
  • Family
  • Glycolipids / immunology*
  • Humans
  • Immunoglobulin M / analysis*
  • Infant
  • Korea / epidemiology
  • Leprosy / epidemiology*
  • Leprosy / transmission
  • Middle Aged
  • Mycobacterium leprae / immunology
  • Philippines / epidemiology
  • Seroepidemiologic Studies


  • Antigens, Bacterial
  • Glycolipids
  • Immunoglobulin M
  • phenolic glycolipid I, Mycobacterium leprae