Dynamics of the self-assembly of unilamellar vesicles

Phys Rev Lett. 2005 Jan 28;94(3):038303. doi: 10.1103/PhysRevLett.94.038303. Epub 2005 Jan 28.


We have studied the transient stages in the formation of unilamellar vesicles with millisecond time resolution. The self-assembly was initiated by rapid mixing of equimolar amounts of anionic and zwitterionic micelles and the transient micellar entities were probed by time-resolved small-angle x-ray scattering. Within the mixing time, original micelles transformed to disklike micelles which evolved further to a critical size and then closed to form monodisperse unilamellar vesicles within a second. Subsequent growth led to an unexpected broadening of the vesicle size distribution.

Publication types

  • Comparative Study
  • Evaluation Study

MeSH terms

  • Crystallization / methods*
  • Kinetics
  • Lipid Bilayers / chemistry*
  • Liposomes / chemistry*
  • Macromolecular Substances / chemistry
  • Membrane Fluidity*
  • Models, Chemical*
  • Models, Molecular*
  • Molecular Conformation
  • Particle Size
  • Solutions


  • Lipid Bilayers
  • Liposomes
  • Macromolecular Substances
  • Solutions