Antigens of Mycobacterium Tuberculosis Recognized by Antibodies During Incipient, Subclinical Tuberculosis

Clin Diagn Lab Immunol. 2005 Feb;12(2):354-8. doi: 10.1128/CDLI.12.2.354-358.2005.

Abstract

Serum samples obtained from human immunodeficiency virus (HIV)-infected tuberculosis (TB) patients months prior to clinical TB were used to delineate the profile of Mycobacterium tuberculosis culture filtrate proteins recognized during subclinical TB. A subset of approximately 12 antigens was recognized by antibodies in these serum samples. Antibodies to two of these antigens (81 [88]-kDa malate synthase [GlcB] and MPT51) were present in serum samples obtained during incipient subclinical TB in 19 (approximately 90%) of the 21 HIV-infected TB patients tested. These antigens will be useful for devising diagnostic tests that can identify HIV-positive individuals who are at a high risk for developing clinical TB.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antibodies, Bacterial / blood*
  • Antigens, Bacterial / genetics
  • Antigens, Bacterial / immunology*
  • Base Sequence
  • HIV Infections / complications*
  • Humans
  • Molecular Sequence Data
  • Molecular Weight
  • Mycobacterium tuberculosis / immunology*
  • Mycobacterium tuberculosis / isolation & purification
  • Tuberculosis / diagnosis*

Substances

  • Antibodies, Bacterial
  • Antigens, Bacterial