A hybrid between the antifungal azole eberconazole and the alkaloid onychine

Pharmazie. 2005 Jan;60(1):5-7.

Abstract

The 9-imidazolylazafluorene 3, a hybrid between the antifungal azole eberconazole and the alkaloid onychine, was prepared from onychine in two steps. This product shows moderate antifungal activity, but, in contrast to other azoles, is not an inhibitor of ergosterol biosynthesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemical synthesis*
  • Alkaloids / pharmacology*
  • Antifungal Agents / chemical synthesis*
  • Antifungal Agents / pharmacology*
  • Cycloheptanes / chemical synthesis*
  • Cycloheptanes / pharmacology*
  • Flavanones
  • Fungi / drug effects
  • Imidazoles / chemical synthesis*
  • Imidazoles / pharmacology*
  • Indicators and Reagents
  • Magnetic Resonance Spectroscopy
  • Microbial Sensitivity Tests
  • Pyridones
  • Spectrophotometry, Infrared

Substances

  • Alkaloids
  • Antifungal Agents
  • Cycloheptanes
  • Flavanones
  • Imidazoles
  • Indicators and Reagents
  • Pyridones
  • onychine
  • eberconazole