Allergic contact dermatitis from povidone-iodine: a re-evaluation study

Contact Dermatitis. 2005 Jan;52(1):9-10. doi: 10.1111/j.0105-1873.2005.00479.x.


500 consecutive patients were patch tested with a 10% povidone-iodine (PVP-I) solution, diluted 10 times in water. Readings were made at 2 and 4 days. 14 of the 500 (2.8%) showed a positive test to PVP-I. The 14 positive patients to PVP-I were subjected to a repeated open application test (ROAT) with a PVP-I solution, as is; 2 of the 14 were recorded as positive. It was concluded that only 2 of the 500 patients had true allergic contact dermatitis from PVP-I (0.4%). This study emphasizes the need for more complete investigation, when testing with some allergens, when they share both irritant and allergenic properties, such as PVP-I. The approach is important to rule out false-positive patch test reactions and to assess true clinical relevance.

Publication types

  • Evaluation Study

MeSH terms

  • Allergens / adverse effects*
  • Anti-Infective Agents, Local / adverse effects*
  • Anti-Infective Agents, Local / immunology
  • Belgium
  • Dermatitis, Allergic Contact / etiology*
  • Dermatitis, Allergic Contact / immunology
  • Female
  • Humans
  • Male
  • Patch Tests / methods*
  • Povidone-Iodine / adverse effects*
  • Risk Factors
  • Time Factors


  • Allergens
  • Anti-Infective Agents, Local
  • Povidone-Iodine