Protective effects of a water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi) mycelia and Agaricus blazei murill against X-irradiation in B6C3F1 mice: Increased small intestinal crypt survival and prolongation of average time to animal death

Int J Mol Med. 2005 Mar;15(3):401-6.


Radioprotective effects of a water-soluble extracts from cultured medium of Ganoderma lucidum (Rei-shi) mycelia (designed as MAK) and Agaricus blazei (Agaricus) against the shortening of survival time or the injury of crypt by X-irradiation were investigated in male B6C3F1 mice. MAK and Agaricus at three different doses were mixed into basal diet into biscuits at 5, 2.5 and 1.25% and administered from 1 week before irradiation. MAK (5% group) significantly prolonged animal survival as compared with basal diet group (control group) after 7 Gy of X-ray irradiation at a dose rate of 2 Gy min(-1). At doses of 8, 10 and 12 Gy X-irradiation at a dose rate of 4 Gy min(-1) MAK (5% group) significantly increased crypt survival as compared to other groups. These results suggest that MAK can act as a radioprotective agent.

MeSH terms

  • Agaricus / chemistry*
  • Animals
  • Cell Survival / drug effects
  • Cell Survival / radiation effects
  • Intestine, Small / cytology
  • Intestine, Small / drug effects*
  • Intestine, Small / radiation effects*
  • Male
  • Mice
  • Mycelium / chemistry*
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Regeneration / drug effects
  • Regeneration / radiation effects
  • Reishi / chemistry*
  • Solubility
  • Survival Rate
  • Time Factors
  • Water / chemistry
  • X-Rays*


  • Plant Extracts
  • Water