Reelin, integrin and DAB1 interactions during embryonic cerebral cortical development

Cereb Cortex. 2005 Oct;15(10):1632-6. doi: 10.1093/cercor/bhi041. Epub 2005 Feb 9.


Extracellular matrix-like molecule reelin and cell surface adhesion receptors such as alpha3beta1 integrin can regulate neuronal migration and position in the developing cerebral cortex. Here we show that alpha3beta1 integrin binds to the N-terminal region of reelin, a site distinct from the region of reelin shown to associate with other reelin receptors such as VLDLR/ApoER2. Furthermore, Dab1, a member of the reelin signaling pathway, can complex with the cytoplasmic region of beta1 integrin in a reelin-dependent manner. Thus, alpha3beta1 integrin-reelin interactions may contribute to appropriate neuronal placement in the developing cerebral cortex.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Blotting, Western
  • Cell Adhesion Molecules, Neuronal / genetics
  • Cell Adhesion Molecules, Neuronal / physiology*
  • Cell Movement / genetics
  • Cell Movement / physiology
  • Cerebral Cortex / embryology*
  • Cerebral Cortex / metabolism*
  • Cues
  • Extracellular Matrix Proteins / genetics
  • Extracellular Matrix Proteins / physiology*
  • Female
  • Immunoprecipitation
  • Integrin alpha3beta1 / genetics
  • Integrin alpha3beta1 / physiology*
  • Mice
  • Mutation / physiology
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / physiology*
  • Pregnancy
  • Protein Binding
  • Recombination, Genetic
  • Reelin Protein
  • Serine Endopeptidases / genetics
  • Serine Endopeptidases / physiology*


  • Cell Adhesion Molecules, Neuronal
  • Dab1 protein, mouse
  • Extracellular Matrix Proteins
  • Integrin alpha3beta1
  • Nerve Tissue Proteins
  • Reelin Protein
  • Reln protein, mouse
  • Serine Endopeptidases