Helper-dependent adenoviral vectors for gene therapy

Hum Gene Ther. 2005 Jan;16(1):1-16. doi: 10.1089/hum.2005.16.1.


Helper-dependent adenoviral vectors possess a number of characteristics that make them attractive gene therapy vectors. These vectors are completely devoid of viral coding sequences and are able to mediate high-efficiency transduction in vivo to direct sustain high-level transgene expression with negligible chronic toxicity. This review focuses on advances in helper-dependent adenoviral vector technology, selected examples of in vivo studies of particular interest, and the issue of vector-mediated acute toxicity.

Publication types

  • Review

MeSH terms

  • Adenoviridae / genetics*
  • Gene Transfer Techniques
  • Genetic Therapy / methods*
  • Genetic Vectors*
  • Helper Viruses / genetics*
  • Humans