Body mass index and blood glucose: correlations with serum insulin, growth hormone, and insulin-like growth factor-1 levels in patients with diffuse idiopathic skeletal hyperostosis (DISH)

Rheumatol Int. 2006 Feb;26(4):292-7. doi: 10.1007/s00296-005-0588-8. Epub 2005 Feb 10.


Obesity is a frequent co-morbid condition associated with diffuse idiopathic skeletal hyperostosis (DISH). Serum growth hormone (GH), insulin-like growth factor (IGF-1) and insulin are significantly elevated in patients with DISH. In this study, we examined the relationship between body mass index (BMI) and basal serum GH, IGF-1, and insulin concentration in a group of 36 DISH patients. Basal serum insulin levels were significantly elevated (P<0.001) in DISH patients with a BMI>28 kg m(-2), classified as obese, compared with DISH patients with BMI ranging from 23 to 28 kg m(-2). In addition, BMI strongly positively correlated with serum insulin concentration in DISH patients (adjusted r2 = 0.348, P<0.001). However, BMI did not correlate with either basal serum GH (adjusted r2 = -0.013) or IGF-1 levels (adjusted r2 = -0.010) in DISH. We conclude that BMI does not seem to contribute to elevated serum GH and IGF-1 levels in symptomatic DISH.

MeSH terms

  • Age Factors
  • Blood Glucose / analysis*
  • Body Mass Index*
  • Human Growth Hormone / blood*
  • Humans
  • Hyperglycemia / blood
  • Hyperostosis, Diffuse Idiopathic Skeletal / blood*
  • Hyperostosis, Diffuse Idiopathic Skeletal / diagnosis
  • Insulin / blood*
  • Insulin-Like Growth Factor I / analysis*
  • Obesity / blood*
  • Obesity / diagnosis


  • Blood Glucose
  • Insulin
  • Human Growth Hormone
  • Insulin-Like Growth Factor I