Assignment of absolute configuration of 3-hydroxy beta-lactams by the NMR "mix and shake" method

Chirality. 2005 Mar;17(3):131-4. doi: 10.1002/chir.20125.

Abstract

The absolute configurations of several 3-hydroxy beta-lactams were assigned by the NMR "mix and shake" methodology developed by Riguera and co-workers. The results from the NMR study correlated perfectly with the absolute configurations obtained from X-ray crystallographic structure analyses and chiral-phase HPLC data.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Crystallography, X-Ray
  • Magnetic Resonance Spectroscopy*
  • Molecular Conformation
  • Molecular Structure
  • beta-Lactams / chemistry*

Substances

  • beta-Lactams