Radical trifluoromethylation of titanium ate enolate

Yoshimitsu Itoh; Koichi Mikami

doi:10.1021/ol047565a

Radical trifluoromethylation of titanium ate enolate

Org Lett. 2005 Feb 17;7(4):649-51. doi: 10.1021/ol047565a.

Authors

Yoshimitsu Itoh¹, Koichi Mikami

Affiliation

¹ Department of Applied Chemistry, Tokyo Institute of Technology, Tokyo 152-8552, Japan.

PMID: 15704916
DOI: 10.1021/ol047565a

Abstract

The radical trifluoromethylation of ketone titanium ate enolates gave alpha-CF3 ketones in good yields. The use of excess amount of LDA and Ti(OiPr)4 in the preparation of titanium ate enolates is the key to the efficient radical trifluoromethylation. [reaction: see text]

MeSH terms

Esters*
Ethers
Hydrocarbons, Fluorinated
Ketones
Molecular Conformation
Organometallic Compounds / chemistry*
Titanium*

Substances

Esters
Ethers
Hydrocarbons, Fluorinated
Ketones
Organometallic Compounds
titanium ate enolate
trifluoromethyl hypofluorite
Titanium