Human parechovirus 3 and neonatal infections

Emerg Infect Dis. 2005 Jan;11(1):103-5. doi: 10.3201/eid1101.040606.


A third serotype of human parechovirus (HPeV) has been recently isolated from stool specimens of a young Japanese child with transient paralysis. We report 3 additional cases of neonatal sepsis caused by HPeV-3 in the fall of 2001 in Canadian infants 7-27 days old. All children were hospitalized with high fever, erythematous rash, and tachypnea for a median of 5 days. The viruses isolated from nasopharyngeal aspirates grew slowly on tertiary monkey kidney cells and were successfully passaged on Vero cells. The predicted amino acid identity of the VP0-VP3-VP1 region of the three viruses was 74.6%-74.8%, 73.4%-73.6%, and 97.0%-97.1% when compared to HPeV-1, -2, and -3 prototype strains, respectively. Although different, our isolates were closely related; amino acid identity was 99.6%-100% for the last 3 proteins.

Publication types

  • Case Reports

MeSH terms

  • Base Sequence
  • Canada
  • DNA, Viral / analysis
  • Female
  • Humans
  • Infant, Newborn
  • Male
  • Molecular Sequence Data
  • Parechovirus / classification
  • Parechovirus / genetics
  • Parechovirus / isolation & purification*
  • Picornaviridae Infections / diagnosis
  • Picornaviridae Infections / virology*
  • Sepsis / diagnosis
  • Sepsis / virology
  • Sequence Analysis, DNA


  • DNA, Viral