Mammalian SAD kinases are required for neuronal polarization

Science. 2005 Feb 11;307(5711):929-32. doi: 10.1126/science.1107403.

Abstract

Electrical activity in neurons is generally initiated in dendritic processes then propagated along axons to synapses, where it is passed to other neurons. Major structural features of neurons-their dendrites and axons-are thus related to their fundamental functions: the receipt and transmission of information. The acquisition of these distinct properties by dendrites and axons, called polarization, is a critical step in neuronal differentiation. We show here that SAD-A and SAD-B, mammalian orthologs of a kinase needed for presynaptic differentiation in Caenorhabditis elegans, are required for neuronal polarization. These kinases will provide entry points for unraveling signaling mechanisms that polarize neurons.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Apoptosis
  • Axons / physiology
  • Axons / ultrastructure
  • Brain / cytology*
  • Brain / embryology
  • Brain / metabolism
  • Brain Chemistry
  • Cell Differentiation
  • Cell Line
  • Cell Polarity*
  • Cell Shape
  • Cells, Cultured
  • Cerebral Cortex / cytology
  • Cerebral Cortex / embryology
  • Cerebral Cortex / metabolism
  • Dendrites / physiology
  • Dendrites / ultrastructure
  • Hippocampus / cytology
  • Mice
  • Microtubule-Associated Proteins / metabolism
  • Mutation
  • Neurons / cytology*
  • Neurons / physiology*
  • Neurons / ultrastructure
  • Phosphorylation
  • Prosencephalon / cytology
  • Prosencephalon / embryology
  • Prosencephalon / metabolism
  • Protein-Serine-Threonine Kinases / genetics
  • Protein-Serine-Threonine Kinases / physiology*
  • Spinal Cord / chemistry
  • Spinal Cord / embryology
  • tau Proteins / metabolism

Substances

  • Microtubule-Associated Proteins
  • tau Proteins
  • Brsk1 protein, mouse
  • Brsk2 protein, mouse
  • Protein-Serine-Threonine Kinases