An extension and novel solution to the (l,d)-motif challenge problem

Genome Inform. 2004;15(2):63-71.


The (l,d)-motif challenge problem, as introduced by Pevzner and Sze, is a mathematical abstraction of the DNA functional site discovery task. Here we expand the (l,d)-motif problem to more accurately model this task and present a novel algorithm to solve this extended problem. This algorithm is guaranteed to find all (l,d)-motifs in a set of input sequences with unbounded support and length. We demonstrate the performance of the algorithm on publicly available datasets and show that the algorithm deterministically enumerates the optimal motifs.

Publication types

  • Review

MeSH terms

  • Algorithms*
  • Amino Acid Motifs / genetics*
  • Binding Sites / genetics
  • DNA / chemistry*
  • DNA / genetics*
  • Sequence Analysis, DNA / methods*


  • DNA