Abstract
Objective:
To investigate the role and mechanism of Astragalus (AS) and saponins of Panax notoginseng (PNS) in treating type 2 diabetic macroangiopathy.
Method:
94 patients with type 2 diabetic macroangiopathy were divided into two groups randomly: group treated with Simvastatin and group treated with AS and PNS, compared with 40 healthy control subjects. Serum level of MMP-9 and lipid in patients and healthy subjects were measured before and after treatment.
Result:
The serum levels of MMP-9, TG, TC, LDL-C, VLDL-C in patients with type 2 diabetic macroangiopathy were improved, while the levels of HDL-C were decreased. Like Simvastatin AS and PNS had the function of reducing MMP-9 and accommodating lipid metabolism.
Conclusion:
Besides accommodating lipid metabolism, AS and PNS can also reduce the level of serum MMP-9 soas to treat type 2 diabetic macroangiopathy.
Publication types
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Clinical Trial
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Astragalus propinquus* / chemistry
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Diabetes Mellitus, Type 2 / blood
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Diabetes Mellitus, Type 2 / drug therapy
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Diabetes Mellitus, Type 2 / enzymology*
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Diabetic Angiopathies / blood
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Diabetic Angiopathies / drug therapy
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Diabetic Angiopathies / enzymology*
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Drug Combinations
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Drugs, Chinese Herbal / isolation & purification
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Drugs, Chinese Herbal / pharmacology
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Female
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Ginsenosides / isolation & purification
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Ginsenosides / therapeutic use*
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Humans
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Hypolipidemic Agents / therapeutic use*
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Lipids / blood
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Male
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Matrix Metalloproteinase 9 / blood*
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Middle Aged
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Panax / chemistry
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Phytotherapy*
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Plants, Medicinal / chemistry
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Simvastatin / therapeutic use*
Substances
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Drug Combinations
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Drugs, Chinese Herbal
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Ginsenosides
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Hypolipidemic Agents
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Lipids
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Simvastatin
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Matrix Metalloproteinase 9