[Effects of Astragalus and saponins of Panax notoginseng on MMP-9 in patients with type 2 diabetic macroangiopathy]

Zhongguo Zhong Yao Za Zhi. 2004 Mar;29(3):264-6.
[Article in Chinese]

Abstract

Objective: To investigate the role and mechanism of Astragalus (AS) and saponins of Panax notoginseng (PNS) in treating type 2 diabetic macroangiopathy.

Method: 94 patients with type 2 diabetic macroangiopathy were divided into two groups randomly: group treated with Simvastatin and group treated with AS and PNS, compared with 40 healthy control subjects. Serum level of MMP-9 and lipid in patients and healthy subjects were measured before and after treatment.

Result: The serum levels of MMP-9, TG, TC, LDL-C, VLDL-C in patients with type 2 diabetic macroangiopathy were improved, while the levels of HDL-C were decreased. Like Simvastatin AS and PNS had the function of reducing MMP-9 and accommodating lipid metabolism.

Conclusion: Besides accommodating lipid metabolism, AS and PNS can also reduce the level of serum MMP-9 soas to treat type 2 diabetic macroangiopathy.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Astragalus propinquus* / chemistry
  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / drug therapy
  • Diabetes Mellitus, Type 2 / enzymology*
  • Diabetic Angiopathies / blood
  • Diabetic Angiopathies / drug therapy
  • Diabetic Angiopathies / enzymology*
  • Drug Combinations
  • Drugs, Chinese Herbal / isolation & purification
  • Drugs, Chinese Herbal / pharmacology
  • Female
  • Ginsenosides / isolation & purification
  • Ginsenosides / therapeutic use*
  • Humans
  • Hypolipidemic Agents / therapeutic use*
  • Lipids / blood
  • Male
  • Matrix Metalloproteinase 9 / blood*
  • Middle Aged
  • Panax / chemistry
  • Phytotherapy*
  • Plants, Medicinal / chemistry
  • Simvastatin / therapeutic use*

Substances

  • Drug Combinations
  • Drugs, Chinese Herbal
  • Ginsenosides
  • Hypolipidemic Agents
  • Lipids
  • Simvastatin
  • Matrix Metalloproteinase 9