[Study on the antioxidative effect of Safflor Yellow]

Zhongguo Zhong Yao Za Zhi. 2004 May;29(5):447-9.
[Article in Chinese]

Abstract

Objective: To observe the antioxidative effect of Safflor Yellow (SY).

Method: Hydroxyl radical scavenge effect of SY was tested with 1,10-phenanthroline-Fe2+ oxidative assay. Lipid peroxidation of mouse liver suspension was measured with thiobarbituric acid colorimetry technique. Hemocytocatheresis was determined with colorimetry.

Result: Hydroxyl radical could be scavenged by 1.39 to 3.42 g x L(-1) SY dose dependently. Mouse liver suspension peroxidation was inhibited by 77.8 to 776.1 mg x L(-1) SY dosage dependently. Hemocytocatheresis was attenuated by 37.1 to 297.1 mg x L(-1) SY dose dependently.

Conclusion: SY is an antioxidative part of Carthamus tinctorius.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antioxidants / isolation & purification
  • Antioxidants / pharmacology*
  • Carthamus tinctorius* / chemistry
  • Chalcone / administration & dosage
  • Chalcone / analogs & derivatives*
  • Chalcone / isolation & purification
  • Chalcone / pharmacology*
  • Dose-Response Relationship, Drug
  • Flowers / chemistry
  • Free Radical Scavengers / pharmacology
  • Hydroxyl Radical / metabolism
  • Lipid Peroxidation / drug effects*
  • Liver / metabolism
  • Male
  • Mice
  • Plants, Medicinal / chemistry
  • Rabbits

Substances

  • Antioxidants
  • Free Radical Scavengers
  • safflower yellow
  • Hydroxyl Radical
  • Chalcone