P-glycoprotein expression of the human placenta during pregnancy

Placenta. Feb-Mar 2005;26(2-3):268-70. doi: 10.1016/j.placenta.2004.05.013.

Abstract

Objective: To investigate whether the placental expression of P-glycoprotein shows a quantitative difference during pregnancy.

Study design: Villous tissue was collected from chorionic villus samples (13-14 weeks of gestation; n = 3 and 20-25 weeks of gestation; n = 4) and from full-term placentas (38-41 weeks of gestation; n = 28). P-glycoprotein was detected by western blot analysis and quantified by densitometry.

Results: We showed for the first time a significant and progressive two-fold decrease in the mean expression of P-glycoprotein between early and late samples, with a major overlap of values.

Conclusion: As P-glycoprotein appears to be involved in drug extrusion, these data suggest that the placenta's ability to protect the fetus from xenobiotics is greater in early pregnancy than at term.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism*
  • Adult
  • Chorionic Villi / metabolism*
  • Female
  • Gestational Age
  • Humans
  • Maternal-Fetal Exchange / physiology*
  • Pregnancy

Substances

  • ATP Binding Cassette Transporter, Subfamily B, Member 1