A prospective assessment of mortality in chronic spinal cord injury

Spinal Cord. 2005 Jul;43(7):408-16. doi: 10.1038/sj.sc.3101729.


Study design: Prospective mortality study.

Objective: To assess the relationship between comorbid medical conditions and other health-related factors to mortality in chronic spinal cord injury (SCI).

Setting: Boston, MA, USA.

Methods: Between 1994 and 2000, 361 males >/=1 year after injury completed a respiratory health questionnaire and underwent pulmonary function testing. Cause-specific mortality was assessed over a median of 55.6 months (range 0.33-74.4 months) through 12/31/2000 using the National Death Index.

Results: At entry, mean (+/-SD) age was 50.6+/-15.0 years (range 23-87) and years since injury was 17.5+/-12.8 years (range 1.0-56.5). Mortality was elevated (observed/expected deaths=37/25.1; SMR=1.47; 95% CI=1.04-2.03) compared to US rates. Risk factors for death were diabetes (RR=2.62; 95% CI=1.19-5.77), heart disease (RR=3.66; 95% CI=1.77-7.78), reduced pulmonary function, and smoking. The most common underlying and contributing causes of death were diseases of the circulatory system (ICD-9 390-459) in 40%, and of the respiratory system in 24% (ICD-9 460-519).

Conclusions: These results suggest that much of the excess mortality in chronic SCI is related to potentially treatable factors. Recognition and treatment of cardiovascular disease, diabetes, and lung disease, together with smoking cessation may substantially reduce mortality in chronic SCI.

Publication types

  • Clinical Trial
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Age Distribution
  • Aged
  • Cause of Death
  • Chronic Disease
  • Comorbidity
  • Female
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • New England / epidemiology
  • Prevalence
  • Prospective Studies
  • Respiration Disorders / mortality*
  • Risk Assessment / methods*
  • Risk Factors
  • Smoking / mortality*
  • Spinal Cord Injuries / mortality*
  • Survival Analysis