Aspochalamins A-D and aspochalasin Z produced by the endosymbiotic Fungus aspergillus niveus LU 9575. I. Taxonomy, fermentation, isolation and biological activities

J Antibiot (Tokyo). 2004 Nov;57(11):707-14. doi: 10.7164/antibiotics.57.707.

Abstract

Aspochalamins A-D, a family of new cytochalasan antibiotics have been isolated from Aspergillus niveus, an endosymbiotic fungus isolated from the gut of a woodlouse belonging to the family Trichoniscidae. Besides aspochalamins, aspochalasin Z, a new member of the aspochalasin family, as well as the known mycotoxins aspochalasin D and citreoviridins A/C and B were isolated from the mycelium. Aspochalamins showed cytostatic effects towards various tumor cell lines and a weak antibacterial activity against Gram-positive bacteria.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / biosynthesis*
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Antibiotics, Antineoplastic / biosynthesis
  • Antibiotics, Antineoplastic / chemistry
  • Antibiotics, Antineoplastic / pharmacology
  • Aspergillus / classification
  • Aspergillus / metabolism*
  • Bacteria / drug effects
  • Cell Line, Tumor
  • Chromatography, High Pressure Liquid
  • Cytochalasins / biosynthesis*
  • Cytochalasins / chemistry
  • Cytochalasins / pharmacology*
  • Drug Screening Assays, Antitumor
  • Fermentation
  • Humans
  • Microbial Sensitivity Tests
  • Microscopy, Electron, Scanning
  • Spectrophotometry, Ultraviolet

Substances

  • Anti-Bacterial Agents
  • Antibiotics, Antineoplastic
  • Cytochalasins
  • aspochalamin A
  • aspochalamin B
  • aspochalamin C
  • aspochalamin D