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. 2004 Nov;57(11):715-20.
doi: 10.7164/antibiotics.57.715.

Aspochalamins A-D and Aspochalasin Z Produced by the Endosymbiotic Fungus Aspergillus Niveus LU 9575. II. Structure Elucidation

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Aspochalamins A-D and Aspochalasin Z Produced by the Endosymbiotic Fungus Aspergillus Niveus LU 9575. II. Structure Elucidation

Alexandra Holtzel et al. J Antibiot (Tokyo). .
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Abstract

The structures of new cytochalasan fungal metabolites aspochalamins A-D have been elucidated by ESI-FTICR-MS, NMR spectroscopy, and chiral amino acid analysis. Aspochalamins A-D consist of different aspochalasin skeletons connected at position C-19 to the N terminus of the tripeptidic moiety amide anthranoyl-L-alanine-E-didehydrotryptamide. Furthermore, the structure of a new aspochalasin analog, aspochalasin Z, was derived from its molecular mass and NMR data as 10-isopropyl-14-methyl[11]-cytochalasa-6Z,13E,19E-triene-1,21-dione.

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