Mifepristone in abortion care

Semin Reprod Med. 2005 Feb;23(1):82-91. doi: 10.1055/s-2005-864036.


With the addition of a prostaglandin analog, mifepristone allows for successful outpatient termination of pregnancy up to 63 days gestation in 92-99% of women. In the inpatient setting, studies have shown that mifepristone in combination with a prostaglandin analog is also effective as an abortifacient in the late first trimester. In the second trimester, the addition of mifepristone to a prostaglandin regimen has been shown to expedite induction time. At all stages of pregnancy, the use of mifepristone facilitates and ameliorates prostaglandins' expulsive effects on the uterine contents. The rich literature regarding mifepristone in the setting of abortion care has made an important contribution to how physicians treat undesired and problem pregnancies. As with any area of medicine, treatment options provide important flexibility for patients and clinicians alike.

Publication types

  • Historical Article
  • Review

MeSH terms

  • Abortifacient Agents, Steroidal / pharmacology*
  • Abortion, Induced* / history
  • Female
  • History, 19th Century
  • History, 20th Century
  • History, Ancient
  • Humans
  • Mifepristone / pharmacology*
  • Pregnancy
  • Pregnancy Trimester, First
  • Pregnancy Trimester, Second


  • Abortifacient Agents, Steroidal
  • Mifepristone