Antiviral activity of glycyrrhizic acid derivatives against SARS-coronavirus

J Med Chem. 2005 Feb 24;48(4):1256-9. doi: 10.1021/jm0493008.

Abstract

Glycyrrhizin (GL) was shown to inhibit SARS-coronavirus (SARS-CoV) replication in vitro. Here the anti-SARS-CoV activity of 15 GL derivatives was tested. The introduction of 2-acetamido-beta-d-glucopyranosylamine into the glycoside chain of GL resulted in 10-fold increased anti-SARS-CoV activity compared to GL. Amides of GL and conjugates of GL with two amino acid residues and a free 30-COOH function presented up to 70-fold increased activity against SARS-CoV but also increased cytotoxicity resulting in decreased selectivity index.

MeSH terms

  • Animals
  • Antiviral Agents / chemical synthesis*
  • Antiviral Agents / chemistry
  • Antiviral Agents / pharmacology
  • Chlorocebus aethiops
  • Glycyrrhizic Acid / analogs & derivatives*
  • Glycyrrhizic Acid / chemical synthesis*
  • Glycyrrhizic Acid / chemistry
  • Glycyrrhizic Acid / pharmacology
  • SARS Virus / drug effects*
  • SARS Virus / isolation & purification
  • Structure-Activity Relationship
  • Vero Cells
  • Virus Replication / drug effects

Substances

  • Antiviral Agents
  • Glycyrrhizic Acid