Transforming growth factor-beta : biology and clinical relevance

J Biochem Mol Biol. 2005 Jan 31;38(1):1-8. doi: 10.5483/bmbrep.2005.38.1.001.


Transforming growth factor-beta is a pleiotropic growth factor that has enthralled many investigators for approximately two decades. In addition to many reports that have clarified the basic mechanism of transforming growth factor-beta signal transduction, numerous laboratories have published on the clinical implication/application of transforming growth factor-beta . To name a few, dysregulation of transforming growth factor-beta signaling plays a role in carcinogenesis, autoimmunity, angiogenesis, and wound healing. In this report, we will review these clinical implications of transforming growth factor-beta .

Publication types

  • Review

MeSH terms

  • Biology
  • Humans
  • Transforming Growth Factor beta / physiology*


  • Transforming Growth Factor beta