A novel isoform of Cbl-associated protein that binds protein kinase A

Biochim Biophys Acta. 2005 Feb 14;1727(2):145-9. doi: 10.1016/j.bbaexp.2004.12.004. Epub 2004 Dec 28.

Abstract

A novel isoform of Cbl-associated protein (CAP) was identified in a yeast two-hybrid screen for A-kinase anchoring proteins expressed in the heart. CAP is a scaffold protein implicated in insulin signaling and cytoskeleton regulation. The protein kinase A binding site is encoded by a previously unidentified, alternatively spliced exon.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alternative Splicing
  • Amino Acid Sequence
  • Base Sequence
  • Binding Sites
  • Cyclic AMP-Dependent Protein Kinases / genetics
  • Cyclic AMP-Dependent Protein Kinases / metabolism*
  • Exons
  • Humans
  • Microfilament Proteins / genetics
  • Microfilament Proteins / metabolism*
  • Molecular Sequence Data
  • Myocardium / enzymology
  • Protein Isoforms / genetics
  • Protein Isoforms / metabolism
  • Recombinant Proteins / chemistry
  • Recombinant Proteins / metabolism
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Sequence Homology, Nucleic Acid
  • src Homology Domains

Substances

  • Microfilament Proteins
  • Protein Isoforms
  • Recombinant Proteins
  • SORBS1 protein, human
  • Cyclic AMP-Dependent Protein Kinases