Conserved non-genic sequences - an unexpected feature of mammalian genomes

Nat Rev Genet. 2005 Feb;6(2):151-7. doi: 10.1038/nrg1527.


Mammalian genomes contain highly conserved sequences that are not functionally transcribed. These sequences are single copy and comprise approximately 1-2% of the human genome. Evolutionary analysis strongly supports their functional conservation, although their potentially diverse, functional attributes remain unknown. It is likely that genomic variation in conserved non-genic sequences is associated with phenotypic variability and human disorders. So how might their function and contribution to human disorders be examined?

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Base Sequence / genetics
  • Computational Biology
  • Conserved Sequence / genetics*
  • DNA, Intergenic / genetics*
  • Evolution, Molecular*
  • Genetic Variation*
  • Genome*
  • Humans
  • Models, Genetic
  • Phenotype


  • DNA, Intergenic