The natural course of Chlamydia trachomatis infection in asymptomatic Colombian women: a 5-year follow-up study

J Infect Dis. 2005 Mar 15;191(6):907-16. doi: 10.1086/428287. Epub 2005 Feb 9.


The natural course of Chlamydia trachomatis infection and its risk factors were studied in Colombian women with normal cytological results, during a 5-year period. Eighty-two women who were found to be positive for C. trachomatis at the start of the study were studied at 6-month intervals. At each visit, a cervical scrape sample was obtained for detection of C. trachomatis by use of C. trachomatis endogenous-plasmid polymerase chain reaction (PCR)-enzyme immunoassay and VD2-PCR-reverse line blot assay. Of the women studied, 67% had a single-serovar infection, 10% had a mixed-serovar infection, and 23% had an infection with an unidentified type. An inversed rate of clearance of C. trachomatis infection was observed with oral contraceptive use (hazard ratio [HR], 1.7 [95% confidence interval {CI}, 1.1-2.7]) and first sexual intercourse at >/=20 years of age (HR, 4.3 [95% CI, 2.3-8.0]). Serovars of group B (B, D, and E) and C (H, I, J, and K) had a decreased rate of clearance (rate ratio, 0.4 [95% CI, 0.1-0.9]), compared with that for serovars of the intermediate group (F and G). At 4 years of follow-up, 94% of the women had cleared their infections.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Cervix Uteri / microbiology
  • Chlamydia Infections / immunology
  • Chlamydia Infections / microbiology
  • Chlamydia Infections / physiopathology*
  • Chlamydia trachomatis / classification*
  • Chlamydia trachomatis / genetics
  • Chlamydia trachomatis / isolation & purification*
  • Colombia
  • Female
  • Follow-Up Studies
  • Humans
  • Immunoenzyme Techniques
  • Plasmids / genetics
  • Polymerase Chain Reaction / methods
  • Risk Factors
  • Serotyping
  • Specimen Handling / methods