Biological half-life of bromide in the rat depends primarily on the magnitude of sodium intake

Physiol Res. 2005;54(6):639-44.

Abstract

The parallel course of the excretion rates of bromide and sodium ions was demonstrated in adult male and female rats administered simultaneously with potassium 82Br-bromide and 24Na-sodium chloride. The animals were exposed to various intakes of sodium ions accompanied with five different anions: Br-, Cl-, HCO3-, ClO4-, and SCN-. Regardless of the anion accompanying the sodium ion, the excretion rates of 82Br- and 24Na+ ions were proportional to the magnitude of sodium intake in the animals. Hence, we have proved our hypothesis that the biological half-life of bromide depends on the magnitude of sodium intake rather than on the intake of chloride.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bromides / administration & dosage
  • Bromides / pharmacokinetics*
  • Bromides / urine
  • Bromine Radioisotopes
  • Female
  • Half-Life
  • Male
  • Perchlorates / administration & dosage
  • Potassium Compounds / administration & dosage
  • Rats
  • Rats, Wistar
  • Sodium / administration & dosage
  • Sodium / pharmacokinetics*
  • Sodium / urine
  • Sodium Bicarbonate / administration & dosage
  • Sodium Chloride / administration & dosage
  • Sodium Compounds / administration & dosage
  • Sodium Radioisotopes

Substances

  • Bromides
  • Bromine Radioisotopes
  • Perchlorates
  • Potassium Compounds
  • Sodium Compounds
  • Sodium Radioisotopes
  • Sodium Chloride
  • Sodium Bicarbonate
  • sodium perchlorate
  • Sodium
  • potassium bromide