Protein complexes: structure prediction challenges for the 21st century

Curr Opin Struct Biol. 2005 Feb;15(1):15-22. doi: 10.1016/


Only a tiny fraction of the many hundreds of known protein complexes are also of known three-dimensional structure. The experimental difficulties surrounding structure determination of complexes make methods that are able to predict structures paramount. The challenge of predicting complex structures is daunting and raises many issues that need to be addressed. To produce the best models, new prediction methods have to somehow combine partial structures with a mixed bag of experimental data, including interactions and low-resolution electron microscopy images.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Binding Sites
  • Computer Simulation
  • Crystallography / methods*
  • Crystallography / trends
  • Models, Chemical*
  • Models, Molecular*
  • Multiprotein Complexes / analysis
  • Multiprotein Complexes / chemistry
  • Multiprotein Complexes / ultrastructure
  • Protein Binding
  • Protein Conformation
  • Protein Interaction Mapping / methods*
  • Protein Interaction Mapping / trends
  • Proteins / analysis
  • Proteins / chemistry*
  • Proteins / ultrastructure*
  • Sequence Analysis, Protein / methods*
  • Sequence Analysis, Protein / trends
  • Structure-Activity Relationship


  • Multiprotein Complexes
  • Proteins