Cytochrome P450 Enzymes as Catalysts of Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a Tobacco Specific Carcinogen

Chem Res Toxicol. 2005 Feb;18(2):95-110. doi: 10.1021/tx049847p.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Carcinogens / metabolism*
  • Catalysis
  • Cytochrome P-450 Enzyme System / chemistry*
  • Cytochrome P-450 Enzyme System / metabolism*
  • Humans
  • Microsomes / metabolism
  • Nitrosamines / metabolism*
  • Pyridines / metabolism
  • Species Specificity
  • Tobacco / metabolism*

Substances

  • Carcinogens
  • Nitrosamines
  • Pyridines
  • 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone
  • Cytochrome P-450 Enzyme System
  • 4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol