Photoaffinity labeling of P-glycoprotein

Mini Rev Med Chem. 2005 Feb;5(2):165-72. doi: 10.2174/1389557053402738.

Abstract

The aim of the present review is to summarize recent progress in identifying substrate binding domains of P-glycoprotein by photoaffinity labeling. Preferred substrate binding regions have been identified using a number of photoaffinity ligands, including anthracyclines, the quinazoline iodoarylazidoprazosine (IAAP), dihydropyridines, taxanes and propafenones. These studies allowed identification of protein regions, which are involved in ligand interaction.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / chemistry*
  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism
  • Animals
  • Binding Sites
  • Humans
  • Ligands
  • Photoaffinity Labels / chemistry*

Substances

  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Ligands
  • Photoaffinity Labels