Signal transducer and activator of transcription (STAT) signalling and T-cell lymphomas

Immunology. 2005 Mar;114(3):301-12. doi: 10.1111/j.1365-2567.2005.02091.x.


Interaction of cytokines with their cognate receptors leads to the activation of latent transcription factors - the signal transducers and activators of transcription (STAT) proteins - whose biological activities ultimately regulate many critical aspects of cell growth, survival and differentiation. Dysregulation of the JAK-STAT pathway is frequently observed in many primary human tumours, reflecting the importance of this pathway in the maintenance of cellular integrity. Here we review the current progress in STAT structure and function, and the contribution of STAT signalling to the pathogenesis of T-cell lymphomas.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cytokines / physiology
  • DNA-Binding Proteins / physiology*
  • Humans
  • Lymphoma, T-Cell / physiopathology*
  • Milk Proteins
  • STAT3 Transcription Factor
  • STAT5 Transcription Factor
  • Signal Transduction / physiology
  • Skin Neoplasms / physiopathology
  • Trans-Activators / physiology*


  • Cytokines
  • DNA-Binding Proteins
  • Milk Proteins
  • STAT3 Transcription Factor
  • STAT3 protein, human
  • STAT5 Transcription Factor
  • Trans-Activators