Cadherins and catenins in synapse development

Curr Opin Neurobiol. 2005 Feb;15(1):73-80. doi: 10.1016/j.conb.2005.01.001.


Cadherin-catenin complexes have been well established as key regulators of cell adhesion. Recent work has elucidated a pivotal role for these molecules in synaptic assembly, remodelling and plasticity. Far from being mere adhesive scaffolds, cadherins might directly regulate cell signalling to modulate synaptic connectivity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cadherins / physiology*
  • Cytoskeletal Proteins / physiology*
  • Humans
  • Models, Neurological
  • Synapses / physiology*


  • Cadherins
  • Cytoskeletal Proteins