Abstract
Expression of antidiuretic hormone V(2)-receptor, water channel protein aquaporin-2, and cytokines interleukin-1b and interleukin-6 was studied in the kidneys of rats with acute inflammation produced by intraperitoneal injection of lipopolysaccharide in a dose of 250 microg/100 g. Reduced expression of aquaporin-2 and V(2)-receptor led to impairment of concentration capacity in the kidneys and decrease in urine osmolarity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acute Disease
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Animals
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Aquaporin 2
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Aquaporins / physiology*
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Disease Models, Animal
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Escherichia coli
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Inflammation / physiopathology*
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Interleukin-1 / physiology
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Interleukin-6 / physiology
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Kidney / physiopathology*
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Lipopolysaccharides / toxicity
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Male
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Rats
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Rats, Wistar
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Receptors, Vasopressin / physiology*
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Reference Values
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Sodium / blood
Substances
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Aqp2 protein, rat
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Aquaporin 2
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Aquaporins
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Interleukin-1
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Interleukin-6
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Lipopolysaccharides
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Receptors, Vasopressin
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Sodium