Antidiuretic hormone-V2-receptor-aquaporin-2 system in rat kidneys during acute inflammation

Bull Exp Biol Med. 2004 Nov;138(5):452-6. doi: 10.1007/s10517-005-0068-x.

Abstract

Expression of antidiuretic hormone V(2)-receptor, water channel protein aquaporin-2, and cytokines interleukin-1b and interleukin-6 was studied in the kidneys of rats with acute inflammation produced by intraperitoneal injection of lipopolysaccharide in a dose of 250 microg/100 g. Reduced expression of aquaporin-2 and V(2)-receptor led to impairment of concentration capacity in the kidneys and decrease in urine osmolarity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Animals
  • Aquaporin 2
  • Aquaporins / physiology*
  • Disease Models, Animal
  • Escherichia coli
  • Inflammation / physiopathology*
  • Interleukin-1 / physiology
  • Interleukin-6 / physiology
  • Kidney / physiopathology*
  • Lipopolysaccharides / toxicity
  • Male
  • Rats
  • Rats, Wistar
  • Receptors, Vasopressin / physiology*
  • Reference Values
  • Sodium / blood

Substances

  • Aqp2 protein, rat
  • Aquaporin 2
  • Aquaporins
  • Interleukin-1
  • Interleukin-6
  • Lipopolysaccharides
  • Receptors, Vasopressin
  • Sodium