The role of insulin and IGF-1 signaling in longevity

Cell Mol Life Sci. 2005 Feb;62(3):320-43. doi: 10.1007/s00018-004-4297-y.


There are many theories of aging and parameters that influence lifespan, including genetic instability, telomerase activity and oxidative stress. The role of caloric restriction, metabolism and insulin and insulin-like growth factor-1 signaling in the process of aging is especially well conserved throughout evolution. These latter factors interact with each other, the former factors and histone deacetylases of the SIR family in a complex interaction to influence lifespan.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Aging
  • Animals
  • Humans
  • Insulin / physiology*
  • Insulin-Like Growth Factor I / physiology*
  • Longevity / physiology*
  • Signal Transduction / physiology*


  • Insulin
  • Insulin-Like Growth Factor I