Mycobacterium tuberculosis infection and FHIT gene alterations in lung cancer

Cancer Lett. 2005 Mar 10;219(2):155-62. doi: 10.1016/j.canlet.2004.06.036.


Although it is fairly well accepted that pulmonary tuberculosis is a major risk factor of lung cancer, the exact molecular mechanisms involved in its tumorigenesis are unclear. For this purpose, we have examined the relationship between Mycobacterium tuberculosis (M-TB) infection and FHIT gene alteration in lung cancer. Tumors with M-TB infection had a slightly higher abnormal FHIT protein expression compared with tumors without M-TB infection, although not statistically significant (Fisher's exact test, P=0.248). LOH affecting at least one locus of the FHIT gene was significantly more frequent in lung cancer patients with M-TB infection than in patients without M-TB infection whether assessment by univariate testing methods or logistic regression modeling analysis (Fisher's exact test P=0.025, logistic regression analysis P=0.012). These results indicate that M-TB infection is associated with FHIT gene LOH in lung cancer.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acid Anhydride Hydrolases / genetics*
  • Female
  • Humans
  • Loss of Heterozygosity
  • Lung Neoplasms / complications
  • Lung Neoplasms / genetics*
  • Male
  • Microsatellite Repeats
  • Middle Aged
  • Neoplasm Proteins / genetics*
  • Oligonucleotide Array Sequence Analysis
  • Tuberculosis, Pulmonary / complications*
  • Tuberculosis, Pulmonary / genetics


  • Neoplasm Proteins
  • fragile histidine triad protein
  • Acid Anhydride Hydrolases