TOR signaling: an odyssey from cellular stress to the cell growth machinery

Curr Biol. 2005 Feb 22;15(4):R139-41. doi: 10.1016/j.cub.2005.02.015.

Abstract

The target of rapamycin (TOR) protein kinase is centrally involved in the coordination of cell growth and proliferation with the availability of growth factors and nutrients. Two recent reports have illuminated a mechanism whereby hypoxic stress dampens TOR signaling in metazoan cells.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Hypoxia / genetics
  • Cell Proliferation*
  • Drosophila Proteins / metabolism*
  • Drosophila melanogaster / genetics
  • Drosophila melanogaster / physiology*
  • Humans
  • Models, Biological*
  • Phosphatidylinositol 3-Kinases / metabolism*
  • Protein Kinases
  • Repressor Proteins / metabolism
  • Signal Transduction*
  • TOR Serine-Threonine Kinases
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*
  • Tuberous Sclerosis Complex 2 Protein
  • Tumor Suppressor Proteins / metabolism

Substances

  • DDIT4 protein, human
  • Drosophila Proteins
  • Repressor Proteins
  • Transcription Factors
  • Tuberous Sclerosis Complex 2 Protein
  • Tumor Suppressor Proteins
  • chrb protein, Drosophila
  • scyl protein, Drosophila
  • Protein Kinases
  • Phosphatidylinositol 3-Kinases
  • target of rapamycin protein, Drosophila
  • TOR Serine-Threonine Kinases