Immunity: it's in our bones

David L Woodland; Marcia A Blackman

doi:10.1016/j.immuni.2005.02.002

Immunity: it's in our bones

Immunity. 2005 Feb;22(2):143-4. doi: 10.1016/j.immuni.2005.02.002.

Authors

David L Woodland¹, Marcia A Blackman

Affiliation

¹ Trudeau Institiute, Inc., Saranac Lake, NY 12983, USA.

PMID: 15723803
DOI: 10.1016/j.immuni.2005.02.002

Abstract

Accumulating data suggest that the bone marrow is a reservoir for memory CD8+ T cells. In this issue of Immunity, show that bone marrow CD8+ T cells are predominantly CCR7+/CD62L+ "central memory" cells and describe specific signals that mediate their constitutive recruitment from the blood.

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MeSH terms

Animals
Bone Marrow / immunology*
CD8-Positive T-Lymphocytes / immunology*
CD8-Positive T-Lymphocytes / metabolism
Humans
Immunologic Memory / immunology*
Signal Transduction