Immunity: it's in our bones

Immunity. 2005 Feb;22(2):143-4. doi: 10.1016/j.immuni.2005.02.002.


Accumulating data suggest that the bone marrow is a reservoir for memory CD8+ T cells. In this issue of Immunity, show that bone marrow CD8+ T cells are predominantly CCR7+/CD62L+ "central memory" cells and describe specific signals that mediate their constitutive recruitment from the blood.

Publication types

  • Comment

MeSH terms

  • Animals
  • Bone Marrow / immunology*
  • CD8-Positive T-Lymphocytes / immunology*
  • CD8-Positive T-Lymphocytes / metabolism
  • Humans
  • Immunologic Memory / immunology*
  • Signal Transduction