Topical retinaldehyde with glycolic acid: study of tolerance and acceptability in association with anti-acne treatments in 1,709 patients

Dermatology. 2005;210 Suppl 1:22-9. doi: 10.1159/000081500.


Background: Retinaldehyde (RAL), a key metabolite between vitamin A and retinoic acid, acts by modulating differentiation and proliferation of keratinocytes, which is of interest in acne lesions, mainly retentional lesions. Glycolic acid increases the exfoliation of corneocytes explaining its mild activity on retentional lesions. Thus, RAL and glycolic acid combined in the same product (Diacneal) have complementary activities which can be of interest for acne patients. The aim of this study was to evaluate the tolerance of Diacneal used by 1,709 acne patients in combination with their usual acne products except retinoids.

Results: This study demonstrated a very good tolerance of Diacneal when used with other acne treatments for 90 days. Complaints about side-effects were rare. Moreover, the significant decrease in both inflammatory and retentional lesions between day 0 and day 90 indicates that Diacneal could amplify the efficiency of other anti-acne products used at the same time by the patients. The subjective evaluation of the preparation's efficacy by investigators and patients was strongly favourable.

Conclusion: These data show that a combination of RAL 0.1% and glycolic acid 6% may be used in association with other topical anti-acne treatments (benzoyl peroxide and topical antibiotics) with an excellent tolerance.

Publication types

  • Clinical Trial
  • Multicenter Study

MeSH terms

  • Acne Vulgaris / drug therapy*
  • Administration, Cutaneous
  • Adolescent
  • Adult
  • Child
  • Dermatologic Agents / administration & dosage
  • Dermatologic Agents / therapeutic use*
  • Drug Combinations
  • Female
  • Glycolates / administration & dosage
  • Glycolates / therapeutic use*
  • Humans
  • Keratolytic Agents / administration & dosage
  • Keratolytic Agents / therapeutic use*
  • Male
  • Middle Aged
  • Patient Compliance
  • Patient Satisfaction
  • Prospective Studies
  • Retinaldehyde / administration & dosage
  • Retinaldehyde / therapeutic use*
  • Treatment Outcome
  • Wound Healing / drug effects


  • Dermatologic Agents
  • Drug Combinations
  • Glycolates
  • Keratolytic Agents
  • diacneal
  • glycolic acid
  • Retinaldehyde