Management of acute cough: comparisons between Belgian and Dutch GPs

Eur J Gen Pract. 2004 Dec;10(4):152-6. doi: 10.3109/13814780409044303.


Objectives: In Europe there are large variations in overall outpatient antibiotic use, even between two neighbouring countries as Belgium and the Netherlands. We aimed to compare the management of acute cough between Belgian and Dutch general practitioners (GPs).

Methods: In cross-sectional studies in Belgium and the Netherlands, 71 Belgian and 84 Dutch GPs included adult patients consulting for acute cough. Differences in antibiotic prescription rates, the percentage of first-choice antibiotics (i.e. tetracyclines and broad-spectrum penicillins) and bronchodilator prescription rates were assessed by using Generalised Estimates Equations to adjust for clustering of patients within GPs.

Results: In Belgium 324/810 patients (40%) were prescribed an antibiotic compared with 101/309 (33%) in the Netherlands (adjusted OR (95% CI) 1.28 (0.91-1.83)). Belgian GPs prescribed fewer first-choice antibiotics compared with Dutch GPs: 124/324 (38%) versus 67/101 (66%) (adjusted OR (95% CI) 0.39 (0.22-0.72)). In both countries, 17% of the patients were prescribed a bronchodilator.

Conclusions: Antibiotic prescription rates for adult patients with acute cough were not significantly higher in Belgian than in Dutch general practice at the 5% significance level. Dutch GPs' antibiotic prescriptions were more in line with national guidelines. Bronchodilator prescription rates were similar. Because Dutch GPs probably encountered more severe cases of acute cough compared with their Belgian colleagues, the observed prescribing differences might be underestimated.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Adult
  • Anti-Bacterial Agents / therapeutic use
  • Belgium
  • Bronchodilator Agents / therapeutic use
  • Cough / drug therapy*
  • Cross-Sectional Studies
  • Drug Utilization / statistics & numerical data
  • Female
  • Humans
  • Male
  • Netherlands
  • Patient Satisfaction / statistics & numerical data
  • Physicians, Family*
  • Practice Patterns, Physicians'*


  • Anti-Bacterial Agents
  • Bronchodilator Agents