[Primary hypothyroidism presenting with amenorrhea, galactorrhea, hyperprolactinemia and enlarged pituitary]

Harefuah. 1992 Jan 15;122(2):76-8.
[Article in Hebrew]


The combination of amenorrhea, galactorrhea, and hyperprolactinemia in a young woman usually suggests a prolactin-secreting adenoma of the anterior pituitary gland. Primary thyroid failure may also be associated with hyperprolactinemia, galactorrhea and suprasellar enlargement of the pituitary. 2 women, aged 23 and 28, respectively, presented with the latter syndrome. 1 was even a candidate for neurosurgery. However, because serum TSH and prolactin levels were elevated, thyroxin replacement therapy was started. It induced normal menses, galactorrhea stopped, and in follow-up CT scans the pituitary become normal in size. Hyperprolactinemia with secondary hypothyroidism, caused by a pituitary adenoma, must be distinguished from primary hypothyroidism, also a cause of hyperprolactinemia.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Adenoma / diagnosis
  • Adult
  • Amenorrhea / etiology*
  • Diagnosis, Differential
  • Female
  • Galactorrhea / etiology*
  • Humans
  • Hyperplasia
  • Hyperprolactinemia / etiology*
  • Hypothyroidism / complications
  • Hypothyroidism / diagnosis*
  • Hypothyroidism / drug therapy
  • Pituitary Gland / pathology*
  • Pituitary Gland, Anterior
  • Pituitary Neoplasms / diagnosis
  • Thyroxine / therapeutic use


  • Thyroxine