The road to survival goes through PARG

Cell Cycle. 2005 Mar;4(3):397-9. doi: 10.4161/cc.4.3.1559. Epub 2005 Mar 24.


Unlike poly(ADP-ribose) polymerase-1 (PARP-1), poly(ADP-ribose) glycohydrolase (PARG) has long been a difficult protein to study. However, the complete absence of PARG activity was recently characterized in mice via disruption of the murine PARG gene. As expected, PARG is critical for the maintenance of steady-state poly(ADP-ribose) levels. But surprisingly, the disruption of PARG led to embryonic lethality and increased susceptibility to mild cell stress. Therefore, the protective role of PARG and its involvement in development indicate that these roads to viability go through PARG.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Cycle*
  • Cell Survival
  • DNA Damage
  • Gene Expression Regulation*
  • Glycoside Hydrolases / genetics*
  • Glycoside Hydrolases / physiology*
  • Mice
  • Mice, Transgenic
  • Models, Biological
  • Mutation
  • Polymers / chemistry


  • Polymers
  • Glycoside Hydrolases
  • poly ADP-ribose glycohydrolase