The relationship between the systemic inflammatory response and survival in patients with transitional cell carcinoma of the urinary bladder

Br J Cancer. 2005 Feb 28;92(4):625-7. doi: 10.1038/sj.bjc.6602406.

Abstract

The relationship between tumour stage, grade, elevated C-reactive protein concentration (<10/>10 mg l(-1)), adjuvant therapy and survival was examined in patients with biopsy proven bladder cancer (n=105). On multivariate analysis stage (HR 3.37, 95% CI 1.37-8.29, P=0.008), grade (HR 2.01, 95% CI 1.14-3.57, P=0.017) and preoperative C-reactive protein (HR 3.31, 95% CI 1.09-10.09, P=0.035) were independently associated with cancer-specific survival.

MeSH terms

  • Aged
  • Analysis of Variance
  • C-Reactive Protein / metabolism
  • Carcinoma, Transitional Cell / blood
  • Carcinoma, Transitional Cell / complications*
  • Carcinoma, Transitional Cell / mortality*
  • Carcinoma, Transitional Cell / pathology
  • Carcinoma, Transitional Cell / therapy
  • Confidence Intervals
  • Disease-Free Survival
  • Female
  • Humans
  • Male
  • Middle Aged
  • Odds Ratio
  • Survival Analysis
  • Systemic Inflammatory Response Syndrome / blood
  • Systemic Inflammatory Response Syndrome / complications*
  • Systemic Inflammatory Response Syndrome / mortality*
  • Urinary Bladder Neoplasms / blood
  • Urinary Bladder Neoplasms / complications*
  • Urinary Bladder Neoplasms / mortality*
  • Urinary Bladder Neoplasms / pathology
  • Urinary Bladder Neoplasms / therapy

Substances

  • C-Reactive Protein