Stimuli responsive polymers for biomedical applications

Chem Soc Rev. 2005 Mar;34(3):276-85. doi: 10.1039/b406727d. Epub 2005 Feb 8.


Polymers that can respond to external stimuli are of great interest in medicine, especially as controlled drug release vehicles. In this critical review, we consider the types of stimulus response used in therapeutic applications and the main classes of responsive materials developed to date. Particular emphasis is placed on the wide-ranging possibilities for the biomedical use of these polymers, ranging from drug delivery systems and cell adhesion mediators to controllers of enzyme function and gene expression (134 references).

Publication types

  • Review

MeSH terms

  • Biocompatible Materials / administration & dosage
  • Biocompatible Materials / chemistry*
  • Cell Adhesion / physiology
  • Chemistry, Pharmaceutical
  • Drug Delivery Systems*
  • Enzymes / metabolism
  • Gene Expression
  • Hydrogen-Ion Concentration
  • Models, Chemical
  • Polymers / administration & dosage
  • Polymers / chemistry*
  • Temperature


  • Biocompatible Materials
  • Enzymes
  • Polymers