In the future, the increasing number of older individuals will play an even greater social and medicopolitical role. One challenge for dermatology is to incorporate preventive or anti-aging measures into daily practice. Solid understanding of the mechanisms of aging is required. An organized approach to such patients with emphasis on history, physical examination, imaging and skin physiology studies, and laboratory diagnosis is presented. Topical and systemic interventions should be based on the results of this complete evaluation.