Genetic mapping on the mouse X chromosome of human cDNA clones for the fragile X and Hunter syndromes

Genomics. 1992 Apr;12(4):814-7. doi: 10.1016/0888-7543(92)90314-i.


Murine X-linked genes corresponding to the human Fragile X (FMR1) and Hunter syndrome (IDS) loci have been mapped in an interspecific backcross between B6CBA-Aw-J/A-Bpa and Mus spretus using human cDNA clones. Pedigree analysis of recombinants from a total of 248 backcross progeny favors a gene order of (Cf-9, Mcf-2)-(Fmr-1)-Ids-Gabra3-Rsvp. Gene order is conserved between the species, although no fragile site has been detected in the mouse in this region of the murine X chromosome.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Chromosome Fragile Sites
  • Chromosome Fragility
  • Chromosome Mapping
  • Crosses, Genetic
  • DNA / genetics*
  • Female
  • Fragile X Syndrome / genetics*
  • Humans
  • Male
  • Mice
  • Mucopolysaccharidosis II / genetics*
  • Recombination, Genetic
  • Species Specificity
  • X Chromosome*


  • DNA